L’attività di Tadalafil si basa sull’inibizione enzimatica di PDE5 con conseguente aumento del guanosin monofosfato ciclico intracellulare. Questo meccanismo induce prolungata vasodilatazione a livello muscolare liscio. Il metabolismo epatico attraverso ossidazione produce derivati inattivi, eliminati principalmente con la bile. L’esposizione sistemica rimane stabile anche in seguito a somministrazioni ripetute. Per le sue proprietà farmacocinetiche, cialis generico italia è frequentemente inserito nei profili comparativi degli inibitori PDE5 a lunga durata.

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